Perineural invasion in endometriotic lesions contributes to endometriosis-associated pain
نویسندگان
چکیده
منابع مشابه
Nerve fibres in ovarian endometriotic lesions in women with ovarian endometriosis.
BACKGROUND Although nerve fibres are present in eutopic and ectopic endometrium, it is unclear whether they appear in ovarian endometriotic lesions. We investigated the presence of nerve fibres in ovarian endometriotic lesions and its correlation with clinical parameters in women with ovarian endometriosis. METHODS Histological sections of ovarian endometriotic lesions from 61 women with ovar...
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Salivary adenoid cystic carcinoma (SACC) has a unique tendency for perineural invasion (PNI), which results in tumor recurrence and poor prognosis. Recent studies have shown that the chemokine CCL5 and its receptor CCR5 play important roles in tumor invasion and metastasis. However, the role of the CCL5/CCR5 axis in the PNI of SACC has not been studied to date. In the present study, we evaluate...
متن کاملPeripheral changes in endometriosis-associated pain.
BACKGROUND Pain remains the cardinal symptom of endometriosis. However, to date, the underlying mechanisms are still only poorly understood. Increasing evidence points towards a close interaction between peripheral nerves, the peritoneal environment and the central nervous system in pain generation and processing. Recently, studies demonstrating nerve fibres and neurotrophic and angiogenic fact...
متن کاملhormonal treatment for endometriosis associated pelvic pain
background: endometriosis is a common gynecological problem associated with chronic pelvic pain. objective: to evaluate the effectiveness of current hormonal treatments of endometriosis associated pain. materials and methods: randomized controlled studies identified from databases of medline and cochrane systemic review groups were pooled. 7 rcts were recruited for evaluation in this review. da...
متن کاملCurrent research in perineural invasion of cholangiocarcinoma
BACKGROUND Perineural invasion is a common path for cholangiocarcinoma (CCA) metastasis, and it is highly correlated with postoperative recurrence and poor prognosis. It is often an early event in a disease that is commonly diagnosed in advanced stages, and thus it could offer a timely therapeutic and diagnostic target if better understood. This article systematically reviews the progress of CC...
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ژورنال
عنوان ژورنال: Journal of Pain Research
سال: 2018
ISSN: 1178-7090
DOI: 10.2147/jpr.s168715