Perinatal growth restriction decreases diuretic action of furosemide in adult rats
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Perinatal growth restriction decreases diuretic action of furosemide in adult rats.
Perinatal growth restriction programs higher risk for chronic disease during adulthood via morphological and physiological changes in organ systems. Perinatal growth restriction is highly correlated with a decreased nephron number, altered renal function and subsequent hypertension. We hypothesize that such renal maladaptations result in altered pharmacologic patterns for life. Maternal protein...
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FUROSEMIDE (4 chloro-N[2-furyl methyl] -5-sulfamyl-anthranilic acid) (fig. 1) is a new and potent diuretic compound which is effective when given either orally or parenterally. Structurally it has in common with substituted thiazides a sulfamyl-benzene grouping. Animal studies have revealed it to be a most effective diuretic in both rats and dogs, resulting in maximum diuretic effects of up to ...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2014
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2014.01.056