Perinatal exposure to a high-fat diet alters proopiomelanocortin, neuropeptide Y and dopaminergic receptors gene expression and the food preference in offspring adult rats

Abstract Exposure to the hight-fat diet may alter control of food intake promoting hyperphagia and obesity. The objective this study was investigate effects on dopamine receptors (drd1 drd2), proopiomelanocortin (pomc), neuropeptideY (npy) genes expression, preference in adult rats. Wistar female rats were fed a or during pregnancy lactation. offspring allocated into groups: Lactation – Control (C) High-fat (H). Post-weaning (CC), mothers C, after weaning; Hight-fat (CH), (HC), H, with (HH), H weaning. groups CH HH presented greater expression drd1 comparison CC. drd2 HC higher gene than did pomc other groups. also CH. npy relation HC. have had for high-fat at 102º life’s day. altered drd1, drd2, npy, influencing diet.