Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine.
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چکیده
منابع مشابه
Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor.
The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R antagonists as antiallergy drugs and to address the question of whether H(1)R ligands bind to hH(4)R. In an acute murine asthma model, the H(1)R antago...
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Introduction: The elevated endogenous opioid tone in cholestasis is associated with changes including an increase in the nociception threshold. We aimed to study the effect of chlorpheniramine and hydroxyzine, H1-receptor antagonists, on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis. Methods: Cholestasis was induced by ligation of main bile duct using ...
متن کاملComparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever.
Ninety patients participated in a randomised, double blind, placebo controlled comparison of terfenadine with astemizole in the treatment of hay fever. They entered the trial as a cohort before the grass pollen season and recorded daily their symptoms of itching eyes, sneezing, running nose, and blocked nose on visual analogue scales in diary cards. Over the eight weeks of the trial astemizole ...
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The aim of this study was to assess the effects of exogenous histamine and H1 and H2 central receptorson electrocardiographic (ECG) parameters, heart rate and mean electrical axis in broiler chickens. For thispurpose, Ross broiler chickens (750-800 g weight) received intracerebroventricularly (ICV) histamine.Moreover, to determine the receptors involved in histamine-induced alterations in ECG c...
متن کاملEffects of administration of histamine and its H1, H2, and H3 receptor antagonists into the primary somatosensory cortex on inflammatory pain in rats
Objective(s): The present study investigated the effects of microinjection of histamine and histamine H1, H2, and H3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (PSC) on inflammatory pain. Material and Methods: Two stainless steel guide canulas were bilaterally implanted into the PSC of anaesthetized rats. Inf...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1982
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1982.tb01356.x