Performance Assessment of a Lateral Flow Rapid Test (SsRapid®) Compared with Two Commercial ELISAs in Detecting Strongyloides Infection
نویسندگان
چکیده
ABSTRACT. Approximately 600 million people worldwide are infected with Strongyloides stercoralis . Many diagnostic laboratories use serology to detect the infection. SsRapid ® is a prototype IgG4 lateral flow test based on NIE recombinant protein. We compared two commercial IgG-ELISAs (Bordier and Euroimmun) using five sera groups (G1–5, N = 170). Healthy individuals from nonendemic areas (G1, 33) larvae-positive patients (G2, 20) showed no significant difference ( P > 0.05) among three assays. The group of other parasitic infections (G3) that results were more concordant Bordier ELISA (73%, 35/48) than Euroimmun (65%, 31/48). In corticosteroid-treated cancer who polymerase chain reaction–positive for Strongyloide s (G4, 25), higher detection rate (28%, 7/25) both ELISAs (4%, 1/25). Meanwhile, significantly less infection prevalence endemic area population (G5) ELISAs. Overall, good performance in detecting IgG-ELISAs.
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ژورنال
عنوان ژورنال: American Journal of Tropical Medicine and Hygiene
سال: 2023
ISSN: ['0002-9637', '1476-1645']
DOI: https://doi.org/10.4269/ajtmh.22-0592