Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor
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Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor.
Although central PYY delivery potently increases food intake, the sites of action and mechanisms mediating these hyperphagic effects are not fully understood. The present studies investigate the contribution of lateral parabrachial nucleus (lPBN) PYY-Y receptor signaling to food intake control, as lPBN neurons express Y receptors and receive PYY fibers and are known to integrate circulating and...
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Pontine parabrachial nucleus (PBN) neurons integrate visceral, oral, and other sensory information, playing an integral role in the neural control of feeding. Current experiments probed whether lateral PBN (lPBN) leptin receptor (LepRb) signaling contributes to this function. Intra-lPBN leptin microinjection significantly reduced cumulative chow intake, average meal size, and body weight in rat...
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1 2 3 Peptide YY signaling in the lateral parabrachial nucleus increases food intake 4 through the Y1 receptor 5 6 Running Title: lPBN PYY-Y1R signaling increases food intake 7 8 Amber L. Alhadeff1, Danielle Golub1, Matthew R. Hayes2, Harvey J. Grill1 9 1Department of Psychology, 2Department of Psychiatry 10 University of Pennsylvania, Philadelphia, PA 19104 11 12 13 14 15 16 17 18 Correspondin...
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Wilson, John D., Danielle M. Nicklous, Vincent J. Aloyo, and Kenny J. Simansky. An orexigenic role for -opioid receptors in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol 285: R1055–R1065, 2003; 10.1152/ajpregu.00108.2003. The pontine parabrachial nucleus (PBN) has been implicated in regulating ingestion and contains opioids that promote feeding elsewhere in the brain....
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The blockade of the lateral parabrachial nucleus (LPBN) with GABA(A) receptor agonist muscimol induces robust hypertonic NaCl and water intake by rats. In the present study we investigated the effects of previous injections of losartan (AT(1) angiotensin receptor antagonist) into the LPBN on 0.3M NaCl and water intake induced by muscimol injected bilaterally in the same area in fluid replete ra...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Endocrinology and Metabolism
سال: 2015
ISSN: 0193-1849,1522-1555
DOI: 10.1152/ajpendo.00346.2015