منابع مشابه
Membrane enhanced peptide synthesis.
This communication reports a new technology platform that advantageously combines organic solvent nanofiltration (a newly emerging technology capable of molecular separations in organic solvents) with solution phase peptide synthesis-Membrane Enhanced Peptide Synthesis (MEPS).
متن کاملAutomatic multiple peptide synthesis.
85 I There is a demand for synthetic peptides for inves3-hydroxy-4-0x0 3,4-dihydro-l,2,3-benzotriazine, tigations such as antibody binding studies, synthetic vaccines and peptide antigens. Often only small quantities of material are needed, e.g. 5-10 mg, amounts often below the useful capacity of a conventional peptide synthesizer. Where large numbers of peptides are needed, such as studies of ...
متن کاملPeptide synthesis: chemical or enzymatic
Abbreviations: CD: circular dichroism CLEC: cross linked enzyme crystals DDC: double dimer constructs ESI: electrospray ionization HOBT: hydroxybenzotriazole HPLC: high performance liquid hromatography KCS: kinetically controlled synthesis MALDI: matrix-assisted laser desorption ionization MAP: multiple antigen peptide system MS: mass spectrometry NMR: nuclear magnetic resonance SPS: solution p...
متن کاملRapid flow-based peptide synthesis.
A flow-based solid-phase peptide synthesis methodology that enables the incorporation of an amino acid residue every 1.8 min under automatic control or every 3 min under manual control is described. This is accomplished by passing a stream of reagent through a heat exchanger into a low volume, low backpressure reaction vessel, and through a UV detector. These features enable continuous delivery...
متن کاملBorinic acid catalysed peptide synthesis.
The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly ...
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ژورنال
عنوان ژورنال: Nature
سال: 1972
ISSN: 0028-0836,1476-4687
DOI: 10.1038/240307b0