Peptide Mimotopes ofNeisseria meningitidisGroup B Capsular Polysaccharide

Unrelated Antibodies Peptide Mimotope Can Bind to Two Capsular Polysaccharide of 6B Serotype: A Peptide Mimotopes of Pneumococcal

Monoclonal antibodies specific for Neisseria meningitidis group B polysaccharide and their peptide mimotopes.

From five mice immunized with Escherichia coli K1 bacteria, we produced 12 immunoglobulin M hybridomas secreting monoclonal antibodies (MAbs) that bind to Neisseria meningitidis group B (NMGB). The 12 MAbs also bound the capsular polysaccharide (PS) of E. coli K1 [which, like NMGB, is alpha(2-8)-linked polysialic acid (PSA)] and bound to EV36, a nonpathogenic E. coli K-12 strain producing alpha...

Study of various presentation forms for a peptide mimetic of Neisseria meningitidis serogroup B capsular polysaccharide.

The formulation of a broadly protective vaccine to prevent the serogroup B Neisseria meningitidis (MenB) disease is still an unmet medical need. We have previously reported the induction of bactericidal and protective antibodies against MenB after immunization of mice with a phage-displayed peptide named 4 L-5. This peptide mimics a capsular polysaccharide (CPS) epitope in MenB. With the aim of...

Chitinases and Peptide Mimotopes

high-affinity chitin binding region [4]. Five homologs of the plant chitinases have been identified in A. fumiga-tus. Only one member of this family has a putative GPI anchor and associated cleavage site (http://www.tigr. org/tdb/e2k1/afu1/), suggesting that this enzyme may Inhibition of glycosylhydrolases by peptides mimick-function in morphogenesis since most of the GPI an-ing carbohydrates o...

Pneumococcal Capsular Polysaccharide Vaccine

Streptococcus pneumoniae (pneumococcus [Pnc]) is a common bacterial agent found in mild mucosal as well as severe systemic infections. Local infections, such as acute otitis media, are rather common; every child has at least one during the first 2 years of life (1), and Pnc is the causative agent in approximately half of the bacterial culturepositive cases (2). Pneumonia is another disease ofte...