Peptide inhibitors MAP the way towards fighting anthrax pathogenesis
نویسندگان
چکیده
منابع مشابه
Fighting anthrax with flies.
A nthrax is an infectious disease caused by the spore-forming bacterium Bacillus anthracis (1, 2). The endospores of the bacterium are remarkably resistant to physical stress and highly infectious (2). In October 2001, the attacks on the World Trade Center were followed by an outbreak of anthrax in the United States after the intentional release of spores through contaminated letters, leading t...
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Inhalation anthrax is a deadly disease for which there is currently no effective treatment. Bacillus anthracis lethal factor (LF) metalloproteinase is an integral component of the tripartite anthrax lethal toxin that is essential for the onset and progression of anthrax. We report here on a fragment-based approach that allowed us to develop inhibitors of LF. The small-molecule inhibitors we hav...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2006
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20060245