Peptide-Functionalized Hydrogel Cubes for Active Tumor Cell Targeting

Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy

Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier. However, further application of CPPs is hindered by lacking selectivity toward targeted cells. The spider venom peptide, lycosin-I, is a CPP with potent cytotoxicity to cancer cells, which might enable lycosin-I to deliver functional materials into cancer ...

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Cancer has become one of the leading causes of mortality globally. The major challenges of conventional cancer therapy are the failure of most chemotherapeutic agents to accumulate selectively in tumor cells and their severe systemic side effects. In the past three decades, a number of drug delivery approaches have been discovered to overwhelm the obstacles. Among these, nanocarriers have gaine...

Modulation of hydrogel nanoparticle intracellular trafficking by multivalent surface engineering with tumor targeting peptide.

Surface engineering of a hydrogel nanoparticle (NP) with the tumor-targeting ligand, F3 peptide, enhances both the NP's binding affinity for, and internalization by, nucleolin overexpressing tumor cells. Remarkably, the F3-functionalized NPs consistently exhibited significantly lower trafficking to the degradative lysosomes than the non-functionalized NPs, in the tumor cells, after internalizat...

Tumor Cell Targeting Peptide Ligands Distinguishing through Color-Encoding Microarray

Biomineralization of A Peptide Hydrogel Scaffold Functionalized with Hydroxyapatite-Binding Peptide

Mustafa Gungormus,* Monica Branco, Hanson Fong,* Candan Tamerler,* Joel P. Schneider and Mehmet Sarikaya* *Genetically Engineered Materials Science and Engineering Center, MSE, U. of Washington, Seattle, WA, USA; #Chemistry and Biochemistry, U. of Delaware, Newark DE, USA Introduction: A major ongoing challenge in the field of reconstructive and regenerative medicine is successful repair or rep...