Peptide-based hydrogen sulphide-releasing gels

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Peptide-based hydrogen sulphide-releasing gels.

An aromatic peptide amphiphile was designed for delivery of the signaling gas H2S. The peptide self-assembled in water into nanofibers that gelled upon charge screening. The non-toxic gel slowly released H2S over 15 hours, and the presence of H2S in endothelial cells was verified using a fluorescent H2S probe.

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AIM Hydrogen sulphide (H2S) intoxication in man is frequently associated with a fatal outcome. In small animal models hydrogen sulphide has demonstrated profound protection against hypoxia. No reports that focus on a potential protective effect in humans have been published. METHODS The frequency and outcome of a large cohort of hydrogen sulphide intoxications is described. RESULTS From 198...

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ژورنال

عنوان ژورنال: Chemical Communications

سال: 2015

ISSN: 1359-7345,1364-548X

DOI: 10.1039/c5cc04883d