Pepsinogen genetics and duodenal ulcer disease.

Serum pepsinogen, a genetic marker in duodenal ulcer.

Study of duodenal ulcer disease in 100 families using total serum pepsinogen as a genetic marker.

Although various markers have been used in attempts to elucidate the mode of inheritance of duodenal ulcer, they have not significantly contributed to a clear understanding of the problem. In the present study total serum pepsinogen was used as a genetic marker and its concentrations were estimated in 100 ulcer patients and their family members up to three generations. Eighty three per cent of ...

Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients.

Cigarette smoking has been linked with duodenal ulcer disease although the mechanism of this association is unclear. This study assessed basal gastric secretory response to acute smoking of smokers with an active duodenal ulcer; in addition the possible effects of chronic smoking on gastric secretory capacity, as expressed by pentagastrin stimulated gastric acid secretion and fasting serum peps...

Duodenal ulcer in sickle cell disease.

Duodenal Ulcer

hardly possible, but all this has been changed by the aggression of surgery in the field of the physician; happily changed, for though postmortem records of duodenal ulcers were common enough it was not until 1883 that Chvostec for the first time made a diagnosis verified at autopsy. Cordivilla of Bologna inaugurated the surgery of chronic duodenal ulcer in 1893 when he successfully operated on...