Peppermint Leaf Extract Cream Increased Transforming Growth Factor β (TGF-β) Expression and Collagen Amount In The Male Wistar Rat's Skin Exposed to UVB

Peppermint leaves contain flavonoids, menthofuran, and other phenolic compounds that have antioxidant activity are believed to inhibit collagen degradation in the skin. This study investigated efficacy of a 5% peppermint leaf extract cream increasing transforming growth factor β (TGF-β) expression amount as indicators maintenance male Wistar rats' skin exposed UVB. Method A randomized post-test-only control group design was performed on rats, local strains, aged 2-3 months, with body weights ranging from 180 200 grams. According sample calculation, 21 rats were randomly divided into three groups. The first is (without any treatment). second treated UVB without (UVB-only group), third + After four weeks treatment, tissue samples examined. TGF-β evaluated by immunohistochemical examination, examined Picro-Sirius red staining. Comparative tests measurement results showed significant difference mean among groups (p<0.001). had highest (77.41±5.79% 82.57±2.18%, respectively), followed (63.17±12.22% 74.05±7.15%) UVB-only (50.54±11.10% 65.65±5.56%). Administration effectively increased compared