منابع مشابه
Zingiber officinale extract pre-treatment ameliorates astrocytes activation and enhances neuroprotection in pentylenetetrazol-induced kindling model of epilepsy in mice
Introduction: Recently, herbal medicine is widely used as an alternative and complementary therapy in several neurological disorders such as epilepsy. The anti-inflammatory and neuroprotective effects of Zingiber officinale or ginger have been well-documented. The present study was designed to evaluate the effects of ginger extract pre-treatment on seizures behavior, neuronal density and as...
متن کاملPiracetam prevents pentylenetetrazol kindling-induced neuronal loss and learning deficits
The effect of the nootropic drug piracetam (100 mg/kg) on kindled seizures, kindling-induced learning deficits, and histological alterations due to changes in central excitability was investigated in Wistar rats. The animals were kindled by repeated i.p. injections of an initially subconvulsive dose of pentylenetetrazol (PTZ). As a control, piracetam or physiological saline was given 60 minutes...
متن کاملHippocampal plasticity in the kindling model of epilepsy in rats.
Histochemical and autoradiographic techniques were used to study mossy fiber sprouting which occurs in the hippocampus of kindled rats. In rats kindled by daily stimulation of amygdala or entorhinal cortex, the mossy fibers sprout to innervate the supragranular zone of fascia dentata; this synaptic reorganization was associated with a significant increase in the density of high-affinity kainic ...
متن کاملMyristica fragrans Houtt extract attenuates neuronal loss and glial activation in pentylenetetrazol-induced kindling model
Inflammatory reactions are closely associated with the development and progression of epilepsy. It has been shown that inhibition of pro-inflammatory cytokines, which are released from activated astrocytes and microglia, are considered to be an effective therapeutic approach for the treatment of epileptic disorders. Regarding the anti-inflammatory effects of nutmeg (Myristica fragrans Houtt), t...
متن کاملA mouse kindling model of perimenstrual catamenial epilepsy.
Catamenial epilepsy is caused by fluctuations in progesterone-derived GABA(A) receptor-modulating anticonvulsant neurosteroids, such as allopregnanolone, that play a significant role in the pathophysiology of epilepsy. However, there is no specific mouse model of catamenial epilepsy. In this study, we developed and characterized a mouse model of catamenial epilepsy by using the neurosteroid-wit...
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ژورنال
عنوان ژورنال: Journal of the Turkish Epilepsi Society
سال: 2015
ISSN: 1300-7157
DOI: 10.5505/epilepsi.2015.08108