Pentylenetetrazol-induced seizures strength in diabetic and normal serum glucose elevated male mice
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چکیده
منابع مشابه
Anticonvulsant Activity of Viola tricolor against Seizures Induced by Pentylenetetrazol and Maximal Electroshock in Mice
Background: Recently, there has been much more interest in the use of medicinal plants in search of novel therapies for human neurodegenerative diseases such as epilepsy. In the present study, we investigated the anticonvulsant effects of Viola tricolor (V. tricolor) on seizure models induced by pentylenetetrazol (PTZ) and maximal electroshock stimulation (MES). Methods: Totally, 260 mice were ...
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Introduction: Epilepsy is a neurological disorder caused by uncontrollable discharge of neurons in the brain. After a seizure oxidative stress play an important role in the oxidative neuronal damage. In this study, we evaluated the anticonvulsant and antioxidant effects of pioglitazone, a PPAR-γ agonist that is used in type2 diabetes, on pentylenetetrazol-induced seizure in mice. Methods: In t...
متن کاملIvabradine Reduces Seizures in Pentylenetetrazol- Kindled Mice
Methods: Forty Mice were randomly allocated into 4 equal groups; control, PTZ, diazepam (4mg/kg) and ivabradine (10 mg/kg) groups. Kindling model was produced by repeated i.p. administration of PTZ (40mg/kg), every other day for 9 days. Repeated PTZ treatment progressively increased the seizure score with the maximum score reached on day 9. Diazepam and ivabradine were administered intraperiton...
متن کاملMontelukast reduces seizures in pentylenetetrazol-kindled mice.
Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phen...
متن کاملEffect of berberine on pentylenetetrazol-induced seizures in rats
Objective: Antiepileptic drugs (AEDs) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current AEDs therapy. Some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. The aim of the p...
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ژورنال
عنوان ژورنال: International Journal of Scientific Reports
سال: 2016
ISSN: 2454-2164,2454-2156
DOI: 10.18203/issn.2454-2156.intjscirep20162806