Pentylenetetrazol-Induced Epileptiform Activity Affects Basal Synaptic Transmission and Short-Term Plasticity in Monosynaptic Connections
نویسندگان
چکیده
منابع مشابه
Pentylenetetrazol-Induced Epileptiform Activity Affects Basal Synaptic Transmission and Short-Term Plasticity in Monosynaptic Connections
Epileptic activity is generally induced in experimental models by local application of epileptogenic drugs, including pentylenetetrazol (PTZ), widely used on both vertebrate and invertebrate neurons. Despite the high prevalence of this neurological disorder and the extensive research on it, the cellular and molecular mechanisms underlying epileptogenesis still remain unclear. In this work, we e...
متن کاملShort-term plasticity optimizes synaptic information transmission.
Short-term synaptic plasticity (STP) is widely thought to play an important role in information processing. This major function of STP has recently been challenged, however, by several computational studies indicating that transmission of information by dynamic synapses is broadband, i.e., frequency independent. Here we developed an analytical approach to quantify time- and rate-dependent synap...
متن کاملPentylenetetrazol-kindling induced synaptic plasticity in the CA1 region of rat hippocampus
The impact of pentylenetetrazol-induced kindling on the effectiveness of theta pattern primed-bursts (PBs) for the induction of long-term potentiation (LTP) of field excitatory postsynaptic potentials (fEPSP) and population spikes (PS) were investigated in hippocampal CA1 of pentylenetetrazol-kindled rats in vivo. The results showed that shortly after kindling, control animals had normal LTP of...
متن کاملSynaptic Plasticity: Short Term
Chemical synapses are rarely static transmitters of information between neurons. Their effectiveness waxes and wanes, depending on the frequency of stimulation and the history of prior activity. At most synapses, repetitive highfrequency action potentials (often called a tetanus) initially result in a rapid growth of successive postsynaptic potential (PSP) amplitudes, called synaptic facilitati...
متن کاملShort-term synaptic plasticity.
Synaptic transmission is a dynamic process. Postsynaptic responses wax and wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic transmission is a crucial determinant of the response properties of synapses and, in turn, of the stimulus properties selected by neural networks and of the patterns of activity generated by those networks. This review focuses on syn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0056968