Penicillinase Studies on L-Phase Variants, G-Phase Variants, and Reverted Strains of Staphylococcus aureus

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Penicillinase Studies on L-Phase Variants, G-Phase Variants, and Reverted Strains of Staphylococcus aureus.

L-phase variants and small colony (G-phase) variants derived from penicillinase-producing Staphylococcus aureus strains were tested for penicillinase (beta lactamase) production. A refined variation of the modified Gots test for penicillinase was used to demonstrate penicillinase synthesis. Penicillinase synthesis was reduced in L-phase variants and G-phase variants when compared to parental st...

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Microcolonies (G-variants) of Staphylococcus aureus.

The persistence or recurrence of bacteria in patients treated with appropriate antimicrobial therapy continues to be a perplexing problem in clinical medicine. Incomplete bactericidal capacity of the host is probably a contributing factor, but of equal importance may be the ability of bacteria to adapt by acquiring a lowered metabolism and a reduced rate of replica-tion. Since most antimocrobia...

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Sensitivity of penicillinase-forming strains of Staphylococcus aureus and of their penicillinase-negative variants to cephaloridine, cephalothin, methicillin, and benzylpenicillin.

Twenty-eight penicillinase-forming cultures of Staphylococcus aureus and their penicillinase-negative variants were examined for resistance to benzylpenicillin, methicillin, cephalothin, and cephaloridine. The results supported the view that cephaloridine was more easily destroyed by staphylococcal penicillinase than was cephalothin. In our tube-dilution tests, the minimum inhibitory concentrat...

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Induction by Antibiotics and Comparative Sensitivity of L-phase Variants of Staphylococcus Aureus.

Molander, C. W. (Cedars of Lebanon-Mount Sinai Hospitals, Los Angeles, Calif.), B. M. Kagan, H. J. Weinberger, E. M. Heimlich, and R. J. Busser. Induction by antibiotics and comparative sensitivity of L-phase variants of Staphylococcus aureus. J. Bacteriol. 88:591-594. 1964.-The penicillins, cephalothin, vancomycin, and bacitracin were found to be less inhibitory to the L-phase variants than to...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1970

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.2.5.644-654.1970