Penicillin Therapy of Experimental Endocarditis Induced by Tolerant Streptococcus sanguis and Nontolerant Streptococcus mitis
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چکیده
منابع مشابه
Penicillin therapy of experimental endocarditis induced by tolerant Streptococcus sanguis and nontolerant Streptococcus mitis.
The response of tolerant Streptococcus sanguis and nontolerant Streptococcus mitis infections to penicillin therapy was compared in the rabbit model of endocarditis. The minimal inhibitory and bactericidal concentrations of penicillin were 0.1 and 0.1 mug/ml, respectively, for S. mitis and 0.05 and 6.2 mug/ml, respectively, for S. sanguis. Time-kill studies done in vitro with penicillin concent...
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It is important in order to advance the increasingly successful attack on subacute bacterial endocarditis to be able to produce the disease experimentally and to treat it with new and improved therapeutic regimens. Since endocarditis caused by Streptococcus mitis has not been consistently produced previously in the dog, a study was undertaken in which cardiovascular stress was created by the es...
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We investigated the role of granulocytes during the induction and course of experimental Streptococcus sanguis endocarditis in rabbits by depleting blood granulocytes with nitrogen mustard. The induction of the endocarditis was not influenced by granulocytopenia: the 50% infectious dose was 5.4 X 10(4) colony-forming units in normal and granulocytopenic rabbits. However, granulocytopenia influe...
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It has been asserted that humoral immunity is an important potentiating factor in pathogenesis of infective endocarditis, in that prior immunization to certain bacteria may predispose the host to endocarditis caused by those organisms. If so, possible future vaccination of humans with streptococcal antigens for the prevention of dental caries might increase the susceptibility of the population ...
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The first well documented case of acute pyogenic vertebral osteomyelitis presenting as the initial manifestation of Streptococcus sanguis endocarditis is reported. The importance of suspecting vertebral osteomyelitis in the presence of disc infection and the diagnostic value of imaging procedures are underlined.
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1983
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.23.1.67