Pengaruh Variasi Konsentrasi Chitosan Sebagai Bahan Penghancur Terhadap Sifat Fisik Sediaan Orally Disintegrating Tablet (ODT) Paracetamol

An antipyretic analgesic drug called paracetamol is used in children to treat mild moderate pain and fever. Orally Disintegrating Tablet (ODT), a medicine that dissolves seconds, was created help who have difficulty swallowing tablets. The purpose of this study determine the effect changes concentration chitosan as disintegrant formulation ODT paracetamol. These tablets are made using wet granulation process. Paracetamol were produced three formulations with 3.5% concentration; 7% 14%. findings showed optimal 3.5%, which had an impact on physical characteristics dissolution results F1 preparation best formula. This caused by average weight uniformity test value 202.65±2.00 mg; diameter thickness 0.831±0.008 cm 0.343±0.008 cm, hardness 5.4±0.34 kg; brittleness 0.23±0.02; disintegration time 24 seconds; da 99.56%. for (p= 0.011), friability 0.046), 0.000) all significant variation (p 0.05). It concluded increased increase content. recommended further research be conducted tests whether effective effect.