Pellagra in isoniazid preventive and antiretroviral therapy

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Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.

Eight cases of pellagra, diagnosed on the grounds of neuropathological findings and retrospective study of clinical data, were found among 106 necropsy cases of tuberculosis. Although these eight patients had shown various mental, neurological and gastrointestinal symptoms, as well as skin lesions, the diagnosis of pellagra had not been made clinically. In all the patients, pellagra symptoms ap...

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Isoniazid Preventive Therapy and Risk for Resistant Tuberculosis

In the context of tuberculosis (TB) resurgence, isoniazid preventive therapy (IPT) is increasingly promoted, but concerns about the risk for development of isoniazid-resistant tuberculosis may hinder its widespread implementation. We conducted a systematic review of data published since 1951 to assess the effect of primary IPT on the risk for isoniazid-resistant TB. Different definitions of iso...

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Isoniazid preventive therapy in correctional facilities: a systematic review.

Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide and the main cause of death in correctional facilities in middle- and low-income countries. Due to the closed environment and the concentration of individuals with TB-related risk factors, effective measures are required to control TB in such settings. Isoniazid preventive therapy (IPT) represents an effective and cost...

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Eligibility for Isoniazid Preventive Therapy in South African Gold Mines

SETTING The "Thibela TB" cluster randomised trial of community-wide isoniazid preventive therapy (IPT) to reduce tuberculosis incidence in the South African gold mines. OBJECTIVES To determine the proportion of participants eligible for IPT and the reasons and risk factors for ineligibility, to inform the scale-up of IPT. DESIGN Cross-sectional survey of participants in intervention cluster...

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Acute pellagra in a child under treatment with isoniazid.

Toxic manifestations during isoniazid therapy are encountered in less than 5% of cases treated, and we have been able to trace little mention of them in children in the literature. The drug is now widely used in the treatment of tuberculosis and is universally prescribed as an adjuvant to streptomycin in tuberculous meningitis. The following case report concerns a child who developed pellagra l...

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ژورنال

عنوان ژورنال: IDCases

سال: 2019

ISSN: 2214-2509

DOI: 10.1016/j.idcr.2019.e00550