PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

Camptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this work, camptothecin has been successfully loaded i...

PEGylated Silk Nanoparticles for Anticancer Drug Delivery.

Silk has a robust clinical track record and is emerging as a promising biopolymer for drug delivery, including its use as nanomedicine. However, silk-based nanomedicines still require further refinements for full exploitation of their potential; the application of "stealth" design principals is especially necessary to support their evolution. The aim of this study was to develop and examine the...

PEGylated PLGA nanoparticles for the improved delivery of doxorubicin.

UNLABELLED We hypothesize that the efficacy of doxorubicin (DOX) can be maximized and dose-limiting cardiotoxicity minimized by controlled release from PEGylated nanoparticles. To test this hypothesis, a unique surface modification technique was used to create PEGylated poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating DOX. An avidin-biotin coupling system was used to control pol...

PEGylated silicon nanoparticles: synthesis and characterization.

Silicon nanoparticles were prepared and functionalized with alkene-terminated poly(ethylene oxide) to impart amphiphilic solution properties to the particles.

pegylated superparamagnetic magnetite nanoparticles for magnetic fluid hyperthermia therapy