PEGylated quaternized copolymer/DNA complexes for gene delivery

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PEGylated quaternized copolymer/DNA complexes for gene delivery.

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The efficiency of liposome-mediated gene delivery is greatly enhanced by appropriate decoration of vehicles with cell-specific targeting ligands. However, liposome-DNA complexes may still be opsonized in serum thus ablating any advantage gained. A stealth aspect may therefore be conferred on complexes by poly(ethylene glycol) (PEG) grafting. Here, we examined the effect that degree of PEGylatio...

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ژورنال

عنوان ژورنال: International Journal of Pharmaceutics

سال: 2007

ISSN: 0378-5173

DOI: 10.1016/j.ijpharm.2007.06.044