Pediatric MS patients with a primary progressive-like disease may still have relevant inflammatory activity and may benefit from regular MS treatment

Identifying patients who may benefit from treatment

Active immunotherapy may delay disability in progressive MS.

In this issue of the journal, an epidemiological study using global multiple sclerosis (MS) database is published that investigated prognostic factors in advanced stages of MS. The cohort analysed included prospectively collected data of over 3000 patients with MS, and among various factors comprised demographics, age at onset, disease duration, annualised relapse rate, disability as rated by E...

P 70: Primary Progressive MS and Affecting Genes

Multiple sclerosis is a CNS autoimmune disease configured by demyelination, inflammation, and degeneration of axons. This disease inflict great harms to patients. The most common problem is inability to control musculoskeletal system and decrease in mobility. These consequences could vary from patients to patients. About 10-15% of all MS patients develop primary progressive MS (PPMS). Despite t...

Aryl hydrocarbon receptor activity may serve as a surrogate marker for MS disease activity

MS diagnosis and prognosis is based on a combination of clinical criteria, MRI, and CSF findings. However, we still lack the ability to predict disease course, including relapse frequency and disability progression. Thus, reliable biomarkers of MS risk and prognosis are sorely needed. In this issue of Neurology® Neuroimmunology & Neuroinflammation, Rothhammer et al. suggest that changes in seru...

Olfactory dysfunction in patients with primary progressive MS

OBJECTIVE We tested the hypothesis that olfactory function is more impaired in patients with primary progressive MS (PPMS) than that in relapsing-remitting MS (RRMS). METHODS Standardized olfactory testing was performed in 32 patients with PPMS, 32 patients with RRMS, and 32 healthy controls (HCs). Patients with olfactory dysfunction due to an alternative primary etiology were excluded. The v...