Pediatric lupus nephritis: Management update
نویسندگان
چکیده
منابع مشابه
Update on Lupus Nephritis.
SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis,...
متن کاملManagement of lupus nephritis.
Management of lupus nephritis is relatively nonspecific and includes various immunosuppressive drugs, cytotoxic agents and other modalities directed against the aberrant immune response. Treatment decisions are influenced by the clinical features, histology, response to treatment, relapses, patient consent and tolerance to medications. Guidelines based on available evidence, as to how best to m...
متن کاملUpdate on the treatment of lupus nephritis.
Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. Although the use of aggressive immunosuppression has improved both patient and renal survival over the past several decades, the optimal treatment of LN remains challenging. Improved outcomes have come at the expense of significant adverse effects owing to therapy. Moreover with long-...
متن کاملUpdate on Immune Mechanisms in Systemic Lupus and Lupus Nephritis
Lupus nephritis is a frequent complication of systemic lupus erythematosus. Multiple pathological mechanisms attribute to the pathogenesis of lupus nephritis. These mechanisms can be grossly divided into two groups, extrarenal or intrarenal pathways. A variety of genetic variants break immune tolerance to nuclear autoantigens, as evident from the existence of antinuclear antibodies. Furthermore...
متن کاملManagement of Refractory Lupus Nephritis
Despite the significant advances in the field, up to one-third of lupus nephritis (LN) patients still do not respond adequately to initial immunosuppressive treatment. This group of patients is heterogeneous in terms of clinical presentation (deterioration of glomerular filtration rate, variable degrees of persistent proteinuria, active urine sediment) and the potential for reversion (ongoing k...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Nephrology
سال: 2014
ISSN: 2220-6124
DOI: 10.5527/wjn.v3.i2.16