PEANUT ALLERGY IN ITALY: A UNIQUE ITALIAN PERSPECTIVE

Background Peanut allergy has not been well characterized in Italy. Objective Our aim was to better define the clinical features of peanut Italy and detect proteins involved allergic reactions. Methods A total 22 centers participated a prospective survey over 6-month period. Clinical histories were confirmed by in vivo and/or in vitro diagnostic means all cases. Potential risk factors for occurrence considered. Levels IgE Arachis hypogea (Ara h) 1, 2, 3, 6, 8, 9 profilin measured. Results 395 patients (aged 2-80 years) enrolled. Of participants, 35% reported local reactions, 38.2% systemic 26.6% experienced anaphylaxis. The sensitization profile dominated Ara h (77% sensitized it), whereas pathogenesis-related protein 10 (PR-10) 26% seed storage (SSPs). Sensitization 2S albumins 2 6) or lipid transfer (LTP) associated with more severe symptoms, PR-10 milder symptoms. Cosensitization reduced reactions both 2– LTP-sensitized patients. SSP prevailed younger LTP older (P < .01). occurred mainly northern Italy, Italy's center south. Atopic dermatitis, frequency ingestion, consumption other family members, use butter did seem be onset. Conclusions In is rare country's south north. These sensitizations mutually exclusive. picture differs from that Anglo-Saxon countries.