Peak oxygen consumption is associated with the inotropic reserve in patients with heart failure with reduced ejection fraction undergoing cardiopulmonary testing

Abstract Background The role of cardiopulmonary exercise testing (CPET) in the prognostic evaluation heart failure with reduced ejection fraction (HFrEF) is powerful and well-established. Nevertheless, value CPET predicting left ventricular inotropic reserve HFrEF remains unknown. Purpose investigation possible associations between variables contractile patients HFrEF. Methods Consecutive aged ≥18 years old a diagnosis ≤40%, as assessed by echocardiography, were prospectively enrolled. Demographic clinical data recorded. All subject underwent either Bruce or modified protocol. Peak oxygen consumption (VO2), carbondioxide production (VCO2), minute ventilation to carbon dioxide (VE/VCO2) slope, (VE), VO2/heart rate (HR) values calculated, while hemodynamic parameters during test also measured. Results In total, 191 included analysis. mean age was 58.8±11.8 30 (15.7%) women. Ischemic disease etiology 101 (52.9%) patients, whereas 90 (47.1%) had history dilated cardiomyopathy. time 7.6±.3 minutes. Mean peak VO2 VE/VCO2 slope calculated at 19.1±6.1 ml kg–1 min–1 43.7±10.1, respectively. According values, 70 (37.2%) Weber class A, 57 (29.8%) B, 48 (25.1%) C 15 (7.9%) D. univariate analysis, change rest systolic blood pressure (ΔSBP), which considered reflect reserve, positively correlated (p<0.001), total pulmonary (VE) (p<0.001) (p=0.02). multivariable independently, linearly associated ΔSBP (Figure 1) (β=0.661, p=0.022). Roc it found that cut-off for 16 exhibits 64% sensitivity 60% specificity ΔSBP>40mmHg (area under curve: 0.657, p<0.001 – Figure 2). Conclusion represents an acceptable predictor Funding Acknowledgement Type funding sources: None.