Peak and Trough

Peak and Trough.

Dow Theory’s Peak-and-Trough Analysis Justified

In the analysis of dynamic financial quantities such as stock prices, equity prices, etc., reasonable results are often obtained if we only consider local maxima (“peaks”) and local minima (“troughs”) and ignore all the other values. The empirical success of this strategy remains a mystery. In this paper, we provide a possible explanation for this success. 1 Formulation of the Problem Peak-and-...

The sharp peak-flat trough pattern and critical speculation

We find empirically a characteristic sharp peak-flat trough pattern in a large set of commodity prices. We argue that the sharp peak structure reflects an endogenous inter-market organization, and that peaks may be seen as local “singularities” resulting from imitation and herding. These findings impose a novel stringent constraint on the construction of models. PACS numbers : 01.75+m Science a...

Optimal Pharmacokinetics of Cyclosporine and Tacrolimus Based Relationship Among AUC, Trough and Peak Concentration

Calcineurin inhibitors (CNIs) are maintenance immunosuppressive drugs that have been used as the main therapy for organ transplantation for many years. Of the CNIs, cyclosporine (CYA) and tacrolimus (TAC) are used in clinical practice. The CYA binding protein is cyclophilin and that of TAC is FK-binding protein (FKBP), but both drugs have same mechanism of action: the inhibition of interleukin ...

Reproducibility and Clinical Value of the Trough-to-Peak Ratio of the Antihypertensive Effect

The objectives of our study were to assess the reproducibility of the trough-to-peak ratio (T/P) and to see whether a high T/P is accompanied by more organ protection or vice versa. The study included 175 (mean6SD age, 5169 years) subjects with mild-moderate essential hypertension who had echocardiographic evidence of left ventricular (LV) hypertrophy taken from the SAMPLE study (Study on Ambul...