PDGF receptors are activated in human epiretinal membranes
نویسندگان
چکیده
منابع مشابه
Neurotrophic factor receptors in epiretinal membranes after human diabetic retinopathy.
OBJECTIVE Formation of epiretinal membranes (ERMs) in the posterior fundus results in progressive deterioration of vision. ERMs have been associated with numerous clinical conditions, including proliferative diabetic retinopathy (PDR), but its pathogenic mechanisms are still unknown. This study was conducted to determine whether neurotrophic factor receptors (tyrosine kinase receptors trkA, trk...
متن کاملGanglion cell neurites in human idiopathic epiretinal membranes.
AIM To identify and confirm the presence of neural elements in idiopathic epiretinal membranes removed from patients' eyes during vitrectomy with epiretinal membrane peeling. METHODS Human epiretinal membranes from patients with no other known eye disease and of varying durations were labelled immunohistochemically with antibodies for neurofilament protein, laminin and either vimentin or GFAP...
متن کاملAniseikonia associated with epiretinal membranes.
AIMS To determine whether the computerised version of the new aniseikonia test (NAT) is a valid, reliable method to measure aniseikonia and establish whether aniseikonia occurs in patients with epiretinal membranes (ERM) with preserved good visual acuity. METHODS With a computerised version of the NAT, horizontal and vertical aniseikonia was measured in 16 individuals (mean 47 (SD 16.46) year...
متن کاملPDGF and PDGF receptors in glioma
The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in normal embryonic development, cellular differentiation, and response to tissue damage. Not surprisingly, as it is a multi-faceted regulatory system, numerous pathological conditions are associated with aberrant activity of the PDGFs and their receptors. As we and others have shown, human gliomas, especiall...
متن کاملEpiretinal macular edema associated with thick epiretinal membranes.
High-resolution imaging with spectral-domain optical coherence tomography has identified an unusual group of epiretinal membranes (ERMs) in the presence of lamellar macular holes. These ERMs are unusually thick. The authors present the case of a patient with age-related macular degeneration who developed edema within a thickened ERM in both eyes after cataract surgery. The edema resolved with a...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2009
ISSN: 0014-4835
DOI: 10.1016/j.exer.2008.10.020