<p>Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy</p>

Folic acid-modified diatrizoic acid-linked dendrimer-entrapped gold nanoparticles as nanoprobes for targeted CT imaging of human cervical cancer

Folic acid-modified diatrizoic acid-linked dendrimer-entrapped gold nanoparticles enable targeted CT imaging of human cervical cancer

It has been a great challenge to develop multifunctional fluorescent nanoprobes for tumor-targeted imaging. In this study, we developed folic acid (FA) gold nanoparticles (AuNPs) through diatrozic acid (DTA) linking for in vitro and in vivo targeted imaging of HeLa cervical cancer cells by computed tomography (CT). G5 dendrimers were used as templates to synthesize AuNPs within the interiors of...

Formulation of temozolomide by folic acid-conjugated tri-block copolymer nanoparticles for targeted drug delivery

Introduction: Glioblastoma multiforme (GBM) is the most frequent primary malignant tumor of the brain. But, the treatment of GBM is one of the most problems in cancer therapy because of poor drug penetration across the blood-brain barrier (BBB). Targeting drug delivery system and conjugating targeting moieties was recognized to overcome the poor penetration of chemotherapy drug...

Folic acid-modified mesoporous silica nanoparticles for cellular and nuclear targeted drug delivery.

Site-specific stimuli responsive nanomaterials are an important breakthrough for the improvement of modern therapies in nanomedicine. Mesoporous silica nanoparticles are good candidate for the development of targeted delivery system as their surface can be easily modified with functional groups in order to achieve controlled and specific release. We designed a drug delivery system based on meso...

The Effect of Folic Acid-Conjugated Coated Iron Oxide Nanoparticles in The Radiosensitization of Human Cervical Carcinoma Cell Line at Clinical Electron energies (6MeV)

Background and Purpose: The objective of this study was to investigate the therapeutic effect of Folic Acid-Conjugated polyglycerol coated iron oxide nanoparticles on the radiosensitivity of HeLa cells when irradiated with 6 MeV electron beams. Materials and Methods: Different concentrations of iron oxide nanoparticles (PG-SPIONs and FA-PG-SPIONs (25, 50, 100, 200 µg ml-1)) were synthesized by...