PDE-4-Hemmer verhindert Exazerbationen

Hemmer 6/7

Although flow cytometric DNA ploidy has turned out as a significant predictor of survival in oral squamous cell carcinoma, little is known about the underlying karyotypic structure of gross aneuploidy. We therefore analysed one diploid and 9 aneuploid carcinomas with relative DNA contents between 1.1 and 2.8 by fluorescence in situ hybridization with topologic markers for the centromere (3cen) ...

Treating COPD with PDE 4 inhibitors

While the pathogenesis of chronic obstructive pulmonary disease (COPD) is incompletely understood, chronic inflammation is a major factor. In fact, the inflammatory response is abnormal, with CD8+ T-cells, CD68+ macrophages, and neutrophils predominating in the conducting airways, lung parenchyma, and pulmonary vasculature. Elevated levels of the second messenger cAMP can inhibit some inflammat...

Phosphodiesterase (PDE)-4 Inhibitors and COPD Correlation with Cancer

A new drug for chronic obstructive pulmonary disease has been recently added as a treatment for certain patients. However, new evidences indicate that there might be a connection with lung cancer. It is known that smoking is a major factor that induces chronic pulmonary disease and smoking is associated with lung cancer. The level of connection between phosphodiesterase (PDE)-4 inhibitors and l...

Liquid-State Anomalies and the Stell-Hemmer Core-Softened Potential

We study the liquid anomalies arising from the Stell-Hemmer interaction, using molecular dynamics simulations and approximate 2D solutions. We observe in the liquid phase three types of anomalies: (i) An increase in specific volume upon cooling, (ii) an increase in isothermal compressibility upon cooling, and (iii) an increase in the diffusion coefficient with pressure. We relate the anomalies ...

Verhindert die Statistikausbildung den Fortschritt der Wirtschafts- und Sozialwissenschaften?