PD52-08 ANALYSIS OF RISK FACTORS FOR SURVIVAL AND PROGNOSIS OF PATIENTS WITH VON HIPPEL-LINDAU SYNDROME: A LARGE RETROSPECTIVE STUDY

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging/Surveillance II (PD52)1 Sep 2021PD52-08 ANALYSIS OF RISK FACTORS FOR SURVIVAL AND PROGNOSIS PATIENTS WITH VON HIPPEL-LINDAU SYNDROME: A LARGE RETROSPECTIVE STUDY Kaifang Ma, Kenan Zhang, Jingcheng Zhou, Lin Cai, and Kan Gong MaKaifang Ma More articles by this author , ZhangKenan Zhang ZhouJingcheng Zhou CaiLin Cai GongKan View All Author Informationhttps://doi.org/10.1097/JU.0000000000002079.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION OBJECTIVE: Von Hippel-Lindau (VHL) disease is an autosomal-dominant hereditary cancer syndrome, which characterized a poor prognosis. Renal cell carcinoma central nervous system hemangioblastoma are the most common causes death in VHL disease. Currently, risk factors for survival remain unclear. This study aimed investigate whether influenced clinical factors. METHODS: In retrospective study, we recruited 776 patients from 304 families. Kaplan-Meier plot Cox regression model were used evaluate median assess how was sex, birth year, family history, type, mutation onset age initial symptom. Age-related risks VHL-associated tumors patient compared. RESULTS: The Chinese with 61 years. Patients positive early-onset truncating types had poorer overall VHL-related survival. history (HR:2.32, p=0.014) (HR:3.79, p<0.001) related higher hemangioblastoma. CONCLUSIONS: largest singer-center research indicated that age, type symptom effect on disease, beneficial genetic counselling decision-making. Source Funding: funded National Natural Science Foundation China (No. 81572506 81872081) © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e913-e914 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...