PD44-05 N-CADHERIN ANTAGONISTS N-Ac-CHAVC-NH2 RESCUE IMMUNOSUPPRESS CAUSED BY PD- L1/IDO-1 IN PROSTATE

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (PD44)1 Sep 2021PD44-05 N-CADHERIN ANTAGONISTS N-Ac-CHAVC-NH2 RESCUE IMMUNOSUPPRESS CAUSED BY PD- L1/IDO-1 IN PROSTATE Yi Sun, Jiaoti Huang, Qiang Wei, and Lu Yang SunYi Sun More articles by this author , HuangJiaoti Huang WeiQiang Wei YangLu View All Author Informationhttps://doi.org/10.1097/JU.0000000000002058.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Few prostate cancer patients benefit from current immunotherapies. We therefore aimed explore new strategies change paradigm. METHODS: Human tissues, cell lines in vivo experiments were used determine whether how N-cadherin impacts the production PD-L1 IDO-1. Then, we PC3 bearing humanized nonobese diabetic/severe combined immunodeficiency IL2Rγnull (hNSG) mice with an intravenous injection human CD34+ haematopoietic stem cells into tail vein test if antagonists (designated ADH-1) could improve therapeutic effect tumour-infiltrating lymphocyte (TIL)-related treatment. RESULTS: dramatically upregulated expression IDO-1 through IFN-g signalling, which be reversed knockout. In preclinical experiments, immune reconstitution obtained TILs slowed tumour growth extended survival time; however, disappeared after system suppression Furthermore, ADH-1 effectively reduced immunosuppression enforced TIL-related therapy. CONCLUSIONS: These data show that antagonist promotes TIL antitumour responses. This important hurdle must overcome for tumours generate a response immunotherapy. Source Funding: study was supported National Natural Science Foundation China (Grant No. 81370855, 81300627, 81702536, 81770756 81200551) L.Y. Q.W., key research development program SQ2017YFSF090096) Prostate Cancer Young Investigator Award 2013, &Technology Department Sichuan Province 2015SZ0230, 2013SZ0006 2013SZ0093) Programs Technology 2018JY0089 2017HH0063) University 2017, Scientific Project Health (No. 120203) Guangdong Applied (2019A1515110125) J.J. The (grant no. 81860454) J.G. © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e738-e739 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...