<p>Biodegradable Polymers for Gene-Delivery Applications</p>
نویسندگان
چکیده
منابع مشابه
Cationic lipids and polymers for gene delivery
Gene therapy, aiming to eradicate causes rather than symptoms of diseases, is believed to be the therapy of the future. A new promising area for the application of gene therapy is the emerging field of regenerative medicine, where gene delivery can be used to enhance or modify cell functions in an organ/tissue or in engineered substitutes. The aim of gene therapy is to achieve the expression of...
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Polycations have been successfully used as gene transfer vehicles both in vitro and in vivo; however, their cytotoxicity has been associated with increasing molecular weight. Polymers that can be rapidly degraded after internalization are typically better tolerated by mammalian cells compared to their non-degradable counterparts. Here, we report the use of a dibromomaleimide-alkyne (DBM-alkyne)...
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The complex nature of in vivo gene transfer establishes the need for multifunctional delivery vectors capable of meeting these challenges. An additional consideration for clinical translation of synthetic delivery formulations is reproducibility and scale-up of materials. In this review, we summarize our work over the last five years in developing a modular approach for synthesizing peptide-bas...
متن کاملAlginate Polymers for Drug Delivery
Acknowledgements We would like to express our gratitude to everyone who advised and assisted with our research throughout our time at ENSIC. We sincerely appreciate their time and efforts. Abstract The goal of this project was to investigate the properties of alginate stabilized emulsions and their potential role for drug delivery. The polymer acts as a barrier between phases in oil-in-water em...
متن کاملPolymers in Drug Delivery
Polymers are being used extensively in drug delivery due to their surface and bulk properties. They are being used in drug formulations and in drug delivery devices. These drug delivery devices may be in the form of implants for controlled drug delivery. Polymers used in colloidal drug carrier systems, consisting of small particles, show great advantage in drug delivery systems because of optim...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2020
ISSN: 1178-2013
DOI: 10.2147/ijn.s222419