PB2078 A RELATIVE ADVANTAGE OF STEM CELL TRANSPLANTATION (SCT) IN PATIENTS WITH LESS ADVANCED MYELODYSPLASTIC DSYNDROMES (MDS)
نویسندگان
چکیده
منابع مشابه
Allogeneic stem cell transplantation for elderly patients with myelodysplastic syndrome.
Allogeneic hematopoietic stem cell transplantation (SCT) is well accepted as a curative treatment approach for younger patients with myelodysplastic syndrome (MDS) and has become one of the most frequent indications for allogeneic SCT as reported to the Center for International Blood and Marrow Transplant Research. However, MDS patients are usually elderly with a median age of approximately 75 ...
متن کاملImpact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS).
Allogeneic hematopoietic cell transplantation (HCT) from human leukocyte antigen (HLA) matched related donor (MRD) and matched unrelated donors (MUD) produces similar survival for patients with acute myelogenous leukemia. Whether these results can be extended to patients with myelodysplastic syndromes (MDS) is unknown. Therefore, analysis of post-HCT outcomes for MDS was performed. Outcomes of ...
متن کاملHematopoietic stem cell transplantation for myelodysplastic syndrome.
Allogeneic hematopoietic stem cell transplantation remains the only curative option for myelodysplastic syndrome, but patients with this disease are often older and frail, and treatment-related mortality and morbidity is a major obstacle to be overcome. Treatment of MDS is likely to benefit from the major lines of investigation in the field of allogeneic transplantation, especially intervention...
متن کاملThe molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes.
Global gene expression profiling of highly purified 5q-deleted CD34+CD38(-)Thy1+ cells in 5q- myelodysplastic syndromes (MDSs) supported that they might originate from and outcompete normal CD34+CD38(-)Thy1+ hematopoietic stem cells. Few but distinct differences in gene expression distinguished MDS and normal stem cells. Expression of BMI1, encoding a critical regulator of self-renewal, was up-...
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ژورنال
عنوان ژورنال: HemaSphere
سال: 2019
ISSN: 2572-9241
DOI: 10.1097/01.hs9.0000566796.30986.6f