Pazopanib therapy for cerebellar hemangioblastomas in von Hippel–Lindau disease
نویسندگان
چکیده
منابع مشابه
The natural history of cerebellar hemangioblastomas in von Hippel-Lindau disease.
BACKGROUND AND PURPOSE Cerebellar hemangioblastomas (HBs) are traditionally classified into different morphologic types: cystic and solid. We have observed the progression from solid to cystic and have reviewed the cases seen at the regional von Hippel-Lindau (VHL) clinic to document the frequency of this progression. METHODS A retrospective review of the notes and images of all patients with...
متن کاملSurgical treatment of cerebellar hemangioblastomas
BACKGROUND Hemangioblastomas (HBL) are uncommon tumors of the central nervous system (CNS), corresponding to 1-2.5% of all intracranial tumors. They can present sporadically or in patients with von Hippel-Lindau (VHL) disease and are most often located in the cerebellum, brainstem, and spinal cord. VHL disease is a multiple neoplasia syndrome inherited in an autosomal dominant fashion and cause...
متن کاملHemangioblastomas of the retina: impact of von Hippel-Lindau disease.
PURPOSE To assess the prevalence of von Hippel-Lindau (VHL) disease and prognosis of vision in patients with retinal hemangioblastomas (HBs). METHODS Thirty-six consecutive patients with retinal HBs were treated at Helsinki University Hospital between 1974 and 1998. Detailed neurologic, ophthalmologic, and radiologic examinations; pedigree; mutation analyses; and collection of all relevant cl...
متن کاملMetachronous Pituitary Stalk And Cerebellar Hemangioblastomas In A Patient Without Von Hippel- Lindau Disease: Case Report And Review Of Literature
Background: Hemangioblastomas (HBs) are benign neoplasms of the central nervous system (CNS) that account for 10–15% of posterior fossa tumors in adults. HBs most commonly arise in the cerebellum but also occur in the spinal cord and medulla. They occur sporadically as solitary lesions or in association with von Hippel-Lindau (VHL) disease and are usually multiple. HBs can arise in the supraten...
متن کاملProspective evaluation of radiosurgery for hemangioblastomas in von Hippel-Lindau disease.
To determine the effectiveness of stereotactic radiosurgery (SRS) treatment to central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL), we analyzed long-term results in VHL patients treated with SRS. Patients were enrolled in a prospective VHL natural history study, undergoing SRS treatment of CNS hemangioblastomas. Treatment regimens, serial clinical evaluations, and ...
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ژورنال
عنوان ژورنال: Targeted Oncology
سال: 2012
ISSN: 1776-2596,1776-260X
DOI: 10.1007/s11523-012-0214-0