Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis
نویسندگان
چکیده
منابع مشابه
pax6 (+5a) expression in adipose tissue-derived stem cells induces retinal ganglion cells
glaucoma remains one of the major causes of blindness in today's world. the progressive field of stem cell proposes an exciting potential for discovering novel therapies. here, we report the development of an easy and high throughput method for differentiation of retinal ganglion cells (rgc) and bipolar cells from human adipose tissue-derived mesenchymal stem cells (hadscs) using pax6 (+5a) gen...
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Background: The transcription factor Pax6 is expressed by many cell types in the developing eye. Eyes do not form in homozygous loss-of-function mouse mutants (Pax6Sey/Sey) and are abnormally small in Pax6Sey/+ mutants. Eyes are also abnormally small in PAX77 mice expressing multiple copies of human PAX6 in addition to endogenous Pax6; protein sequences are identical in the two species. The dev...
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During development, retinal ganglion cells (RGCs) extend their axons toward their thalamic and mesencephalic targets. Their navigation is largely directed by guidance cues present in their environment. Since cAMP is an important second messenger that mediates the neural response to guidance molecules and its intracellular levels seem to decrease significantly following birth, we tested whether ...
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An early step in the formation of the optic pathway is the directed extension of retinal ganglion cell (RGC) axons into the optic fiber layer (OFL) of the retina in which they project toward the optic disc. Using analysis of knock-out mice and in vitro assays, we found that, in the mammalian retina, Slit1 and Slit2, known chemorepellents for RGC axons, regulate distinct aspects of intraretinal ...
متن کاملRetinal Ganglion Cells
Segments from adult fish and rat retinae were explanted on myelinmarker expressing oligodendrocytes derived from the regenerating goldfish optic nerve. Fish axons grew in high density and even rat retinal axons regenerated to considerable length on the surface of the fish oligodendrocytes, suggesting that this type of fish glia has axon-growth promoting surface components that exert their influ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-72828-4