Pax6 is misexpressed in Sox1 null lens fiber cells
نویسندگان
چکیده
منابع مشابه
Pax6 is essential for lens fiber cell differentiation.
The developing ocular lens provides an excellent model system with which to study the intrinsic and extrinsic cues governing cell differentiation. Although the transcription factors Pax6 and Sox2 have been shown to be essential for lens induction, their later roles during lens fiber differentiation remain largely unknown. Using Cre/loxP mutagenesis, we somatically inactivated Pax6 and Sox2 in t...
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right ventricle and the outflow tract of the heart. Here we have investigated the role of tailup (tup), the Drosophila homologue of vertebrate islet-1 in the development of the dorsal vessel. In Drosophila, cardiac progenitor cells are specified bilaterally in the dorsal mesoderm, which requires complex interactions between the transcription factors Tinman/Nkx2.5, Pannier/GATA factor, and Dorso...
متن کاملPax6 induces ectopic eyes in a vertebrate.
We report here that misexpression of the transcription factor Pax6 in the vertebrate Xenopus laevis leads to the formation of differentiated ectopic eyes. Multiple molecular markers indicated the presence of mature lens fiber cells, ganglion cells, Müller cells, photoreceptors and retinal pigment epithelial cells in a spatial arrangement similar to that of endogenous eyes. Lineage tracing exper...
متن کاملRequirement for the c-Maf transcription factor in crystallin gene regulation and lens development.
The vertebrate lens is a tissue composed of terminally differentiated fiber cells and anterior lens epithelial cells. The abundant, preferential expression of the soluble proteins called crystallins creates a transparent, refractive index gradient in the lens. Several transcription factors such as Pax6, Sox1, and L-Maf have been shown to regulate lens development. Here we show that mice lacking...
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Activation of the first lens-specific gene of the chicken, delta 1-crystallin, is dependent on a group of lens nuclear factors, deltaEF2, interacting with the delta1-crystallin minimal enhancer, DC5. One of the deltaEF2 factors was previously identified as SOX2. We show that two related SOX proteins, SOX1 and SOX3, account for the remaining members of deltaEF2. Activation of the DC5 enhancer is...
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ژورنال
عنوان ژورنال: Gene Expression Patterns
سال: 2007
ISSN: 1567-133X
DOI: 10.1016/j.modgep.2007.01.001