Patterns of Presentation of Drug-Resistant Tuberculosis in Nigeria: A Retrospective File Review

Background: An understanding of the patterns drug-resistant tuberculosis (DR-TB) is needed to develop best diagnostic tools and decide on optimal treatment combination therapies for management DR-TB in Nigeria. Objective: We aimed investigate five first-line anti-TB drugs over a period seven years (2010–2016) associated clinical socio-demographic factors. Methods: A retrospective study recruited 2555 patients between 2010 2016 across six geopolitical zones determined based standard case definition their association with demographic information. Data were analyzed using Statistical Package Social Sciences (SPSS) software. Independent predictors patterns/types bivariate multivariate analyses statistical significance p < 0.05 95% confidence interval. Results: The majority participants males, 66.93% (1710), 31–40 old, 35.19% (899), previously treated, 77.10% (1909), had received at least two treatments, 411 (49.94%) multi-drug resistant, 61.41% (1165). Southwest zone highest number cases, 36.92%. found an upward trend prevalence from 2016. Participants who one previous showed statistically significant higher rifampicin resistance (59.68%), those treatments reported polydrug (78.57%), three or more multidrug (19.83%) (χ2 = 36.39; 0.001). Mono-drug significantly southwest (29.48% 34.12% respectively), northcentral (20.69%) south-south (20.69%), (30.03%) (19.18%) 98.26; Conclusions: present Clinicians should weigh these while deciding drug combinations optimize outcomes patients. national scale-up plan DST services focus multiple exposures Northeastern country.