Patterns of antigenic diversity and the mechanisms that maintain them

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Patterns of antigenic diversity and the mechanisms that maintain them.

Many of the remaining challenges in infectious disease control involve pathogens that fail to elicit long-lasting immunity in their hosts. Antigenic variation is a common reason for this failure and a contributor to the complexity of vaccine design. Diversifying selection by the host immune system is commonly, and often correctly, invoked to explain antigenic variability in pathogens. However, ...

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ژورنال

عنوان ژورنال: Journal of The Royal Society Interface

سال: 2007

ISSN: 1742-5689,1742-5662

DOI: 10.1098/rsif.2007.0229