Patterns of antibiotic use in hospital-acquired infections

BackgroundMonitoring the use of antimicrobials in hospitalized patients is critical owing to risk resistance selection. This study aimed describe patterns antimicrobial prescription for most frequent healthcare-associated infections (HAIs) France, relating drugs and microbiological data.MethodsWe used data from 2017 point-prevalence survey HAI a large nationally representative sample inpatients. We sought unambiguous correspondence between individual indications antibiotic regimen sites determine which molecules were directed towards pathogen, considering its profile.ResultsAmong 75,698 adult 401 hospitals, 5.1% had an active 4.3% being treated HAI. The two lower respiratory tract (LRTI, 27.7%) urinary (UTI, 18.4%). For LRTI, prescribed was amoxicillin-clavulanic acid (27.6%) frequently isolated pathogens (each accounting around 17% isolates) Staphylococcus aureus, Pseudomonas aeruginosa Escherichia coli. Meticillin-resistant S. aureus LRTI more likely be with linezolid. UTI, ofloxacin, ceftriaxone, amoxicillin/co-amoxiclav most-prescribed (?13% each) E. coli predominantly (52.0%). Extended-spectrum beta-lactamase-producing UTI by fosfomycin, pivmecillinam or ertapenem.ConclusionsThis provides baseline relation information common HAIs. These results can serve direct future efforts stewardship. Our work could extended broader population, notably Europe where similar surveys have been conducted. Monitoring data. profile. Among ertapenem.