Patterns and modes of β-lactam resistance in Pseudomonas aeruginosa
نویسندگان
چکیده
منابع مشابه
Co-regulation of β-lactam resistance, alginate production and quorum sensing in Pseudomonas aeruginosa
Development of β-lactam resistance, production of alginate and modulation of virulence factor expression that alters host immune responses are the hallmarks of chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. In this study, we propose that a co-regulatory network exists between these mechanisms. We compared the promoter activities of ampR, algT/U, lasR, lasI, rhlR, rhlI and...
متن کاملFactors involved in beta-lactam antibiotic resistance in Pseudomonas aeruginosa.
A temperature-sensitive mutant, strain SS, which is assumed to be devoid of beta-lactamase activity and deficient in a permeability barrier to antibiotics, was isolated from a beta-lactamase-less mutant, strain L-2, derived from Pseudomonas aeruginosa IFO 3080. By comparing the beta-lactam antibiotic susceptibility between strains IFO 3080, L-2, and SS, the involvement of both beta-lactamase an...
متن کاملRelation between Resistance to Antipseudomonal β-Lactams and ampC and mexC Genes of Pseudomonas aeruginosa
Background: In order to select a better antibiotic choice for treatment of Pseudomonas aeruginosa infections, this study was conducted to determine the frequency of resistance to some antipseudomonal β-lactams in P. aeruginosa isolates from patients in Tehran, Iran. In addition, the relation between presence of genes known to be responsible for resist...
متن کاملAssociation Between Metallo-β-lactamases and Integrons with Multi-Drug Resistance in Pseudomonas aeruginosa Isolates
Pseudomonas aeruginosa is among the most important pathogens in the nosocomial infections. A genetic mobile element, the integron, is one of the major agents involved in dissemination of multi-drug resistance among gram negative bacteria. During a descriptive study from October 2009 to August 2010, some 130 P. aeruginosa clinical isolates were collected from different wards of three hospitals...
متن کاملHigh β-lactamase levels change the pharmacodynamics of β-lactam antibiotics in Pseudomonas aeruginosa biofilms.
Resistance to β-lactam antibiotics is a frequent problem in Pseudomonas aeruginosa lung infection of cystic fibrosis (CF) patients. This resistance is mainly due to the hyperproduction of chromosomally encoded β-lactamase and biofilm formation. The purpose of this study was to investigate the role of β-lactamase in the pharmacokinetics (PK) and pharmacodynamics (PD) of ceftazidime and imipenem ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 1999
ISSN: 1198-743X
DOI: 10.1111/j.1469-0691.1999.tb00719.x