Patterning Bacterial Cellulose Films with Iron Oxide Nanoparticles and Magnetic Resonance Imaging Monitoring

Biomaterials derived from nature can offer sustainable, biomimetic, and biointeractive solutions. Bacterial cellulose (BC) is a natural biopolymer gaining popularity in the medical field due to its biocompatibility, excellent mechanical properties, animal-free origin. Those attributes, together with optimal conformability different surfaces high water holding capacity, have endorsed use of BC films wound healing, tissue engineering, implants, or wearable sensors. The functionalization nanoparticles (NPs) spatial control their disposition substrate could further boost opportunities those sectors. Here we report on an original method deposit superparamagnetic iron oxide NPs (SPIONs) selected areas flat film (thickness 6 ± 1 μm, roughness 26 3 nm) using screen-printing process create ad hoc patterns surface. ink used for consisted dense solution blended fibers (BCf, length 14 9 μm) previously coated SPIONs microwave-assisted synthetic route. In addition, tested easy identification BC/SPIONs implant inserted simulated by magnetic resonance imaging (MRI) as provided ex vivo test. presented performance transverse relaxation (T2) contrast agent. functionalized enlarge application bioimplants be noninvasively monitored detection deformations adhesions.