Patterned cell culture substrates created by hot embossing of tissue culture treated polystyrene
نویسندگان
چکیده
منابع مشابه
Patterned cell culture substrates created by hot embossing of tissue culture treated polystyrene.
Patterning materials such that they elicit a different cell response in different regions would have significant implications in fields such as implantable biomaterials, in vitro cell culture and tissue engineering and regenerative medicine. Moreover, the ability to pattern polymers using inexpensive, currently available processes, without the need for adding proteins or other biochemical agent...
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Adherent mammalian cells dynamically interact with their extracellular matrix (ECM) and culture substrate. To accommodate this sensitivity, standard culture techniques typically utilize tissue culture polystyrene (TCPS), a treated polystyrene substrate that promotes cell attachment. However, TCPS cannot be easily integrated into microfluidic devices as it is incompatible with conventional fabri...
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Clinically relevant studies of cell function in vitro require a physiologically-representative microenvironment possessing aspects such as a 3D extracellular matrix (ECM) and controlled biochemical and biophysical parameters. A polydimethylsiloxane (PDMS) microfluidic system with a 3D collagen gel has previously served for analysis of factors inducing different responses of cells in a 3D microe...
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Cells respond to and are directed by physiochemical cues in their microenvironment, including geometry and substrate stiffness. The development of substrates for cell culture with precisely controlled physiochemical characteristics has the potential to advance the understanding of cell biology considerably. In this communication, E-jet printing is introduced as a method for creating high-resolu...
متن کاملHot embossing for fabrication of a microfluidic 3D cell culture platform.
Clinically relevant studies of cell function in vitro require a physiologically-representative microenvironment possessing aspects such as a 3D extracellular matrix (ECM) and controlled biochemical and biophysical parameters. A polydimethylsiloxane (PDMS) microfluidic system with a 3D collagen gel has previously served for analysis of factors inducing different responses of cells in a 3D microe...
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ژورنال
عنوان ژورنال: Journal of Materials Science: Materials in Medicine
سال: 2013
ISSN: 0957-4530,1573-4838
DOI: 10.1007/s10856-013-5011-5