Patient Income Level and Cancer Clinical Trial Participation

Sharing clinical trial data on patient level: Opportunities and challenges

In recent months one of the most controversially discussed topics among regulatory agencies, the pharmaceutical industry, journal editors, and academia has been the sharing of patient-level clinical trial data. Several projects have been started such as the European Medicines Agency´s (EMA) "proactive publication of clinical trial data", the BMJ open data campaign, or the AllTrials initiative. ...

Decision making for cancer clinical trial participation: a systematic review.

PURPOSE/OBJECTIVES To describe what is known about the factors that influence cancer clinical trial decision making. DATA SOURCES PubMed database and reference lists of identified articles. DATA SYNTHESIS Variations in research design and methods, including sample characteristics, instrumentation, time between decision made and measurement of decision making, and response rates, have effect...

Barriers to cancer clinical trial participation among Native elders.

OBJECTIVES American Indians/Alaska Natives are underrepresented in clinical trials. Therefore, they must participate in large-scale cancer clinical trials to ensure the generalizability of trial results and improve their access to high-quality treatment. Our goal was to identify factors that influenced participation in cancer clinical trials among American Indians/Alaska Natives. METHODS An a...

ECRI Evidence Report Patients’ Reasons for Participation in Clinical Trials and Effect of Trial Participation on Patient Outcomes

Patient- and trial-specific barriers to participation in cardiovascular randomized clinical trials.

OBJECTIVES The purpose of this study was to quantitatively examine the association of patient- and trial-specific factors with participation in cardiovascular randomized clinical trials. BACKGROUND Randomized clinical trials are central to evidenced-based medicine, but low patient participation rates and potentially modifiable barriers are not well understood. METHODS At a large U.S. academ...