Patient-Derived Xenografts Accurately Capture Clinical Responses to Treatment
نویسندگان
چکیده
منابع مشابه
Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions
The development of novel therapies against melanoma would benefit from individualized tumor models to ensure the rapid and accurate identification of biomarkers of therapy response. Previous studies have suggested that patient-derived xenografts (PDXes) could be useful. However, the utility of PDXes in guiding real-time treatment decisions has only been reported in anecdotal forms. Here tumor b...
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Cancer is among the leading causes of death worldwide. In 2012, approximately 14 million new cases and about eight million cancer-related deaths were reported. In the United States, it is estimated that approximately 1,685,210 new cases of cancer will be diagnosed and 595,690 people will die from the disease (www.cancer.gov). Scientists for many years have been investigating cancer biology in a...
متن کاملPatient-derived tumor xenografts: transforming clinical samples into mouse models.
Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genet...
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The prognosis of uveal melanoma (UM) remains poor due to a high risk of metastatic disease. No effective therapies have been described for metastatic UM, and new therapies are needed to improve the outcome for these patients. To achieve this goal, new preclinical animal models are needed. Existing animal models, including genetically engineered mice and orthotopic xenograft models in immunodefi...
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Patient-derived xenograft (PDX) models for cancer research have recently attracted considerable attention in both the academy and industry (Hidalgo et al., 2014; Wilding and Bodmer, 2014). PDX models have been developed from different tumor types including lung cancer to improve the drug development process. These models are used for pre-clinical drug evaluation and can be used for the predicti...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2014
ISSN: 0923-7534
DOI: 10.1093/annonc/mdu358.4