Patient-derived cell line, xenograft and organoid models in lung cancer therapy
نویسندگان
چکیده
منابع مشابه
establishment of autochthonous & standard cell line derived xenograft models of glioblastoma multiform in iran
background: gbm is the most common and malignant astrocity tumor and it is persistent to common treatment so, these patients have a very low survival. several researchers around the world, including iran, have been investigated gbm-cell line in vitro. however in vivo studies have not been fulfilled. methods : as standard cell line (u-87mg) derived from human gbm and total gbm tumor derived from...
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Traditional preclinical studies of cancer therapeutics have relied on the use of established human cell lines that have been adapted to grow in the laboratory and, therefore, may deviate from the cancer they were meant to represent. With the emphasis of cancer drug development shifting from non-specific cytotoxic agents to rationally designed molecularly targeted therapies or immunotherapy come...
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Recent evidence suggests that patient derived xenograft (PDX) models can maintain certain pathological and molecular features of the original disease. However, these characterizations are limited to immunohistochemistry or by tissue microarray analysis. We conducted a high-throughput sequencing of primary colon tumor and PDX has not been reported yet. Fresh primary colon cancer tissues that ori...
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ژورنال
عنوان ژورنال: Translational Lung Cancer Research
سال: 2020
ISSN: 2218-6751,2226-4477
DOI: 10.21037/tlcr-20-154