Pathway Analysis of Genome Wide Association Studies (GWAS) Data Associated with Male Infertility

Background: Infertility is a common condition affecting approximately 10–20% of the reproductive age population. Idiopathic infertility cases are thought to have genetic basis, but underlying causes largely unknown. However, basis male in humans only partially understood. The Purpose study understand current state research on genetics and its association with significant biological mechanisms. Results: We performed an Identify Candidate Causal SNPs Pathway (ICSN Pathway) analysis using genome-wide (GWAS) dataset, NCBI-PubMed search which included 632 GWAS 451 from PubMed server, respectively. ICSN produced three hypothetical mechanisms associated infertility: (1) rs8084 rs7192→HLA-DRA→inflammatory pathways cell adhesion; rs7550231 rs2234167→TNFRSF14→TNF Receptor Superfamily Member 14→T lymphocyte proliferation activation; rs1105879 rs2070959→UGT1A6→UDP glucuronosyltransferase family 1 member A6→Metabolism Xenobiotics, androgen, estrogen, retinol, carbohydrates. Conclusions: believe that our results may be helpful infertility. Pathway-based methods been applied datasets investigate reported some novel risk pathways. This pathway dataset suggests process related inflammation metabolism might contribute susceptibility. Our contribution operates through multiple genes inflammatory diseases interacting functional