Pathophysiology of subchondral bone erosions in rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Local bone erosions in rheumatoid arthritis
Bone erosion is a hallmark of rheumatoid arthritis. Recent evidence from experimental arthritis suggests that osteoclasts are essential for the formation of local bone erosions. Two essential regulators of osteoclastogenesis have recently been described: the receptor-activator of nuclear factor kappa B ligand, which promotes osteoclast maturation, and osteoprotegerin (OPG), which blocks osteocl...
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Takeuchi et al demonstrate an additional inhibitory effect on the progression of bone erosions in rheumatoid arthritis (RA) with the addition to methotrexate of an anti-receptor activator of nuclear factor kappa-B ligand (RANKL) antibody, denosumab, confirming results already reported 8 years ago by Cohen and colleagues. Insufficient inhibition of structural joint damage by diseasemodifying ant...
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Defects in the superior margin of ribs, of an erosive nature, appear to be uncommon, the chief causes being poliomyelitis (Bernstein, Loeser, and Manning, 1958), hyperparathyroidism (Noetzli and Steinbach, 1962), rheumatoid arthritis (Alpert and Feldman, 1964), scleroderma (Keats, 1967); other rarer causes have been summarized by Boone, Swenson, and Felson (1964), Gayler and Donner (1967), and ...
متن کاملComparing bone mineral density in rheumatoid arthritis and psoriatic arthritis
Background: Changes in patients’ bone mineral density (BMD) is one of the problems in patients with rheumatoid arthritis, which can be due to the use of corticosteroid drugs to reduce patients' symptoms or due to the aging process in patients. In this study, we decided to compare BMD in patients with psoriatic arthritis and rheumatoid arthritis. Methods: This study as a cross-sectional descrip...
متن کاملHealing of erosions in rheumatoid arthritis.
Reports on healing of erosions in rheumatoid arthritis are rare. However, it is expected that repair of erosions should be seen more often during the period of extensive use of disease modifying antirheumatic drugs, especially in patients who experience sustained remission. Two such cases are described.
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2012
ISSN: 1478-6354
DOI: 10.1186/ar3721