Pathophysiology of migraine: an increasingly complex narrative to 2020

Migraine: multiple processes, complex pathophysiology.

Migraine is a common, multifactorial, disabling, recurrent, hereditary neurovascular headache disorder. It usually strikes sufferers a few times per year in childhood and then progresses to a few times per week in adulthood, particularly in females. Attacks often begin with warning signs (prodromes) and aura (transient focal neurological symptoms) whose origin is thought to involve the hypothal...

An increasingly complex code.

Pathophysiology of migraine.

The cause and pathophysiology of migraine are not well understood. Over the years research into migraine pathophysiology has focused on the physiology and pharmacology of the headache, the changes in cerebral cortex associated with the symptoms of the aura, and more recently the genetics underlying the migraine syndromes. In this discussion, the neuroanatomical structures activated during migra...

Migraine – Pathophysiology of Pain

Migraine is a primary episodic headache disorder characterized by a cascade of events that involve various combinations of neurologic, gastrointestinal and autonomic changes. Headache is probably caused by activation of meningeal and blood vessel nociceptors combined with an alteration in central pain modulation. Headache and its associated neuro-vascular changes are subserved by the trigeminal...

[Pathophysiology of migraine chronification].

In approximately 3％ of migraineurs, migraine evolves into more protracted and severe conditions annually. Meanwhile, approximately 26％ of chronic migraine cases regain the episodic nature of migraine headaches in two years. The prevalence of chronic migraine is estimated to be approximately 1％. Although the pathophysiology of migraine chronification is poorly understood, several studies have de...