Pathophysiology and Treatment of Memory Dysfunction After Traumatic Brain Injury

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Pathophysiology of traumatic brain injury

Traumatic brain injury (TBI) is the leading cause of death worldwide in people under the age of 40, and is expected to be the third most common cause of death and disability by the year 2020.1 Each year, it accounts for one million hospital admissions in the European Union2 and 1.7 million in the United States.3 An estimated 43.1% of people discharged after sustaining TBI eventually suffer long...

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Pathophysiology of traumatic brain injury.

Traumatic brain injury (TBI) is considered an epidemic that continues to compromise the welfare of humankind. Despite the extensive efforts invested in countering this clinical health problem, current clinical science and technology still fall short of providing a pharmacological cure for TBI rendering tens of thousands of TBI patients vulnerable to its detrimental sequelae. Over the past 30 ye...

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Autonomic Dysfunction after Mild Traumatic Brain Injury

A mild traumatic brain injury (mTBI) is a complex pathophysiologic process that has a systemic effect on the body aside from solely an impairment in cognitive function. Dysfunction of the autonomic nervous system (ANS) has been found to induce abnormalities in organ systems throughout the body, and may contribute to cardiovascular dysregulation and increased mortality. Autonomic dysfunction, al...

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Posterior pituitary dysfunction after traumatic brain injury.

Disorders of water balance are well recognized after traumatic brain injury (TBI), but there are no reliable data on their true prevalence in post-TBI patients. We aimed to evaluate the prevalence of posterior pituitary dysfunction in a large cohort of survivors of TBI. One hundred two consecutive patients (85 males) who suffered severe or moderate TBI were evaluated for diabetes insipidus (DI)...

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Working memory after severe traumatic brain injury.

The aim of the present study was to assess the functioning of the different subsystems of working memory after severe traumatic brain injury (TBI). A total of 30 patients with severe chronic TBI and 28 controls received a comprehensive assessment of working memory addressing the phonological loop (forward and backward digit span; word length and phonological similarity effects), the visuospatia...

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ژورنال

عنوان ژورنال: Current Neurology and Neuroscience Reports

سال: 2017

ISSN: 1528-4042,1534-6293

DOI: 10.1007/s11910-017-0762-x